Ridaforolimusisasemisyntheticmacrocycliclactonepreparedfromrapamycinbyselectivealkylationofthe42-hydroxygroupwithadimethylphosphinatemoiety.Ridaforolimusisextensivelycitedintheliteraturewithover70citations.
CASNumber
572924-54-0
MolecularFormula
C53H84NO14P
MolecularWeight
990.2
MechanismofAction
Ridaforolimusbindstoreceptorprotein,FKBP12.ThiscomplexthenbindstomTORpreventingitsinteractionwithtargetproteins.
StorageConditions
-20°C