Ridaforolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety. Ridaforolimus is extensively cited in the literature with over 70 citations.
Ridaforolimus is soluble in ethanol, methanol, DMF or DMSO.
CAS Number
572924-54-0
Molecular Formula
C53H84NO14P
Molecular Weight
990.2
Mechanism of Action
Ridaforolimus binds to receptor protein, FKBP12. This complex then binds to mTOR preventing its interaction with target proteins.
Storage Conditions
-20°C