Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Thiolutin suppresses tumor cell-induced angiogenesis in vivo.
Thiolutin is soluble in DMF and DMSO and is moderately soluble in methanol and ethanol.
CAS Number
87-11-6
Molecular Formula
C8H8N2O2S2
Molecular Weight
228.3
Mechanism of Action
Thiolutin is a potent inhibitor of bacterial and yeast RNA polymerases, and also inhibits mannan and glucan formation in fungi.
Storage Conditions
-20°C