LeucinostatinAisthemajorcomponentofanatypicalnonapeptidecomplexproducedbyPaecilomyceslilacinus,firstreportedin1973.LeucinostatinsdisplaybroadbioactivityagainstGrampositivebacteria,fungi,plantsandtumorcelllines.LeucinostatinAispotentiatedbyinhibitorssuchasventuricidinandoligomycin. Morerecently,interestinleucinostatinhasfocusedonunderstandingitsactivityasaninsulin-likegrowthfactorIregulator,anionophore,inhibitorofcellsurfaceexpressionofviralglycoproteinsanditsanti-trypanosomalactivity.
LeucinostatinAissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
76600-38-9
MolecularFormula
C62H111N11O13
MolecularWeight
1218.6
MechanismofAction
LeucinostatinAinhibitsrespirationbyuncouplingoxidativephosphorylation.
StorageConditions
-20°C