Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumor cell lines. Leucinostatin A is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.
Leucinostatin A is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
CAS Number
76600-38-9
Molecular Formula
C62H111N11O13
Molecular Weight
1218.6
Mechanism of Action
Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation.
Storage Conditions
-20°C