Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin is widely used for the treatment of obesity.
Tetrahydrolipstatin is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
96829-58-2
Molecular Formula
C29H53NO5
Molecular Weight
495.7
Mechanism of Action
Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption.
Storage Conditions
-20°C