Temsirolimusisasemisyntheticmacrocycliclactonepreparedfromrapamycinbyselectiveacylationofthe42-hydroxygroupwithaprotectedbis(dihydromethyl)propionicacid,followedbydeprotection.Temsirolimusisextensivelycitedintheliteraturewithover700citations.
Temsirolimusissolubleinethanol,methanol,DMFandDMSO.
CASNumber
162635-04-3
MolecularFormula
C56H87NO16
MolecularWeight
1030.3
MechanismofAction
Temsirolimusbindstoreceptorprotein,FKBP12.ThecomplexthenbindstomTORpreventingitfrominteractingwithtargetproteins.
StorageConditions
-20°C