Everolimusisasemi-syntheticmacrocycliclactonepreparedfromrapamycinbyselectivealkylationofthe42-hydroxygroupwithasilyl-protectedhydroxyethyltriflatemoiety,followedbyadditionofanethylhydroxymoietytoprovidegreaterst
lityandbioavailability.Everolimusisextensivelycitedintheliteraturewithover2,000citations.
Everolimusissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
104987-12-4
MolecularFormula
C43H69NO12
MolecularWeight
954.2
MechanismofAction
Likealltacrolimusanalogues,everolimusbindstoreceptorprotein,FKBP12.ThecomplexthenbindstomTORpreventingitfrominteractingwithtargetproteins.
StorageConditions
-20°C