Kijanimicinisatetronicacidrelatedtosaccharocarcin,chlorothricin,versipelostatinandtetrocarcin.Likethetetrocarcins,kijanimicincontainsanunusualnitroaminoglycoside.Kijanimicinisapotentantibacterial,antimalarialandantitumoractive.Severalmembersofthisclasshavereceivedconsiderableliteraturefocus.VersipelostatininhibitstranscriptionfromthepromoterofGRP78,agenethatisactivatedaspartofastresssignallingpathwayunderglucosedeprivationresultinginunfoldedproteinresponse(UPR).TheUPR-inhibitoryactionisseenonlyinconditionsofglucosedeprivationandcausesselectiveandmassivekillingoftheglucose-deprivedcells.TetrocarcinAappearstotargetthephosphatidylinositide-3"-kinase/Aktsignallingpathway.
Kijanimicinissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
78798-08-0
MolecularFormula
C67H100N2O24
MolecularWeight
1317.5
StorageConditions
-20°C
Specifications: