Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Antibiotics can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.
61177-45-5
Mixture
Mixture
Like other β-lactam antibiotics, the chemical structure of clavulanic acid contains a β-lactam ring allowing it to act as a β-lactamase inhibitor. By forming a covalent bond with inhibiting β-lactamase enzymes, clavulanate allows β-lactam antibiotics to bind and inhibit PBPs (penicillin binding protein) without interference from degredative enzymes.
2933.79.8500
Powder
White or almost white powder
Mixture
≤2.5%
≤0.4 at 278nm
4.8-8.0
48.0-53.5% (on dried basis) (Clavulanic acid potassium)
n-Butanol: ≤5000ppm
Impurity E: ≤1.0%
Impurity G: ≤1.0%
Any other impurity: ≤0.2%
Total Impurities: ≤2.0%
Acetone: ≤5000ppm
