Meropenem with sodium carbonate is a salt form of meropenem; a β-lactam antibiotic in the carbapenem class. Meropenem with sodium carbonate is very soluble in water at approximatley 112 mg/mL.

Molecular Formula

C₁₇H₂₅N₃O₅S • Na₂CO₃

Molecular Weight

466.46

Mechanism of Action

β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.

Storage Conditions

2-8°C

Tariff Code

2941.90.5000

Spectrum

Meropenem has a broad spectrum of activity and has been found to be effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae; a group of pathogenic microbes resistant to many first line beta-lactam antibiotics and certain cephalosporins.

Specifications: