Meropenemisaβ-lactamantibioticinthecarbapenemclassandissparinglysolubleinaqueoussolution(5.63mg/mL). Meropenemhasbeenfoundtobeeffectiveagainstextendedspectrumbeta-lactamase(ESBL)producing Enterobacteriaceae;agroupofpathogenicmicrobesresistanttomanyfirstlinebeta-lactamantibioticsandcertaincephalosporins.
119478-56-7
C17H25N3O5S•3H2O
437.52
β-lactamsinterferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetoβ-lactamsiscommonlyduetocellscontainingplasmidencodedβ-lactamases.Likemanycarbapenems,meropenemishighlyresistanttothedegradativeeffectsofβ-lactamases.
2-8°C
2941.90.5000
Meropenemisabroadspectrumantibiotictargetingawiderangeofbacteriaespeciallythosewhichcausemeningitis.
Powder
Almostwhiteoryellowishcrystallinepowder
Synthetic
ChromotographicPurity:
Anytwomajorimpurities:Notmorethan0.3%
Singleimpurity:Notmorethan0.1%
Totalimpurities:Notmorethan0.3%
11.4-13.4%
4.0-6.0
-17.0°to-21.0°
(OnDriedBasis):98.0-101.0%
≤0.1%
≤10ppm
Acetone:≤0.05%
