Cefoperazone sodium is a third generation cephalosporin antibiotic.  Cefoperazone sodium is freely soluble in aqueous solution (50 mg/mL).

CAS Number

62893-20-3

Molecular Formula

C₂₅H₂₆N₉NaO₈S₂

Molecular Weight

667.65

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefoperazone however, is largely resistant to β-lactamases produced by resistant cells.

Storage Conditions

-20°C

Tariff Code

2941.90.3000

Spectrum

Cefoperazone is primarily limited to gram negative bacteria namely Pseudomonas aeruginosa.

Specifications: