Cefoxitin sodium is a cephamycin β-lactam antibiotic grouped with the second generation cephalosporins.
TOKU-E offers two forms of cefoxitin: cefoxitin (C091) and cefoxitin sodium (C054). In aqueous solution, cefoxitin is sparingly soluble (0.195 mg/mL) and cefoxitin sodium is freely soluble. Both forms have similar potencies and are suitable for microbiology use; however, cefoxitin sodium is easier to work with in aqueous solution because of its higher solubility.
33564-30-6
C16H16N3NaO7S2
449.43
Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephamycins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephamycins, cefoxitin is resistant to β-lactamases.
-20°C
2941.90.5000
Cefoxitin is a broad spectrum antibiotic effective against several gram positive and gram negative bacteria. Like many cephamycins, cefoxitin is particularly effective against anaerobic bacteria.
Powder
White or almost white powder
Semi-synthetic
≤ 1.0%
4.2-7.0
+206° to +214°
Dried Basis:
927 - 970 µg/mg (based on C16H17N3O7S2);
97.5% - 102.0% (based on C16H16N3NaO7S2)
≤0.002%
Acetone: ≤0.7%
Methanol: ≤0.1%
