Cefoxitinsodiumisacephamycinβ-lactamantibioticgroupedwiththesecondgenerationcephalosporins.
TOKU-Eofferstwoformsofcefoxitin:cefoxitin(C091)andcefoxitinsodium(C054).Inaqueoussolution,cefoxitinissparinglysoluble(0.195mg/mL)andcefoxitinsodiumisfreelysoluble.BothformshavesimilarpotenciesandaresuitableformicroBIOLOGyuse;however,cefoxitinsodiumiseasiertoworkwithinaqueoussolutionbecauseofitshighersolubility.
33564-30-6
C16H16N3NaO7S2
449.43
Likeβ-lactams,cephamycinsinterferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetocephamycinsiscommonlyduetocellscontainingplasmidencodedβ-lactamases.Likemanycephamycins,cefoxitinisresistanttoβ-lactamases.
-20°C
2941.90.5000
Cefoxitinisabroadspectrumantibioticeffectiveagainstseveralgrampositiveandgramnegativebacteria.Likemanycephamycins,cefoxitinisparticularlyeffectiveagainstanaerobicbacteria.
Powder
Whiteoralmostwhitepowder
Semi-synthetic
≤1.0%
4.2-7.0
+206°to+214°
DriedBasis:
927-970µg/mg(basedonC16H17N3O7S2);
97.5%-102.0%(basedonC16H16N3NaO7S2)
≤0.002%
Acetone:≤0.7%
Methanol:≤0.1%
