Dasatinibismultitargetkinaseinhibitorusedinthetreatmentofleukemia.Dasatinib"smaintargetsaretyrosinekinaseBCR/ABL,whichworkstoprovidethecancercellwithATPatanuncontrolledratecausingrapiddivision,andtheSRCfamilyofkinases,whichcontributetothemalignantmigrationofcancers.
Dasatinibisslightlysolubleinethanolandmethanol,butinsolubleinwater.
CASNumber
302962-49-8
MolecularFormula
C22H26ClN7O2S
MolecularWeight
488.01
MechanismofAction
DasatinibisabletobindtothekinasedomainofboththeactiveandinactiveformsofBCR/ABLformoreeffectiveinhibitingpower.