FumagillinisapolyenemycotoxinisolatedfromAspergillusfumigatusin1951asapotentantiprotozoanforthetreatmentofamoebiasis.Morerecently,fumagillinhasbeenshowntoinhibitendothelialcellproliferationandangiogenesis.
Fumagillinissolubleinethanol,methanol,DMForDMSO.Poorwatersolubility.
CASNumber
23110-15-8
MolecularFormula
C26H34O7
MolecularWeight
458.6
MechanismofAction
Fumagillininhibitsendothelialcellproliferationandangiogenesisbyinhibitingmethionineaminopeptidase-2(MetAP-2).
StorageConditions
-20°C