Stauprimideisasemi-syntheticanalogueofthestaurosporinefamilyofindolocarbazoles.Stauprimidewasfirstpublishedin1994aspartofanextensivestructure-activityinvestigationtoimprovetheselectiveinhibitionofproteinkinaseCaspotentialantitumoragents.Stauprimideincreasestheefficiencyofthedirecteddifferentiationofmouseandhumanembryonicstemcellsinsynergywithdefinedextracellularsignallingcues.
Stauprimideissolubleinethanol,methanol,DMFandDMSO.
CASNumber
154589-96-5
MolecularFormula
C35H28N4O5
MolecularWeight
584.6
MechanismofAction
StauprimideinteractswithNME2(PUF)transcriptionfactortodown-regulatec-Mycexpression,leADIngtodifferentiationofstemcells.
StorageConditions
-20°C