Doxorubicin (adriamycin) is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumor agent for the treatment of a wide range of cancers. Doxorubicin also exhibits anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.
Doxorubicin is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
23214-92-8
Molecular Formula
C27H29NO11
Molecular Weight
543.5
Mechanism of Action
Doxorubicin antimicrobial activity is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.
Storage Conditions
-20°C