Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.
Reticulol is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
224452-66-8
Molecular Formula
C30H47NO4S
Molecular Weight
517.8
Storage Conditions
-20°C
Specifications: