Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex, and is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. Chrysomycin A has a potent antibacterial, antifungal, antiviral and antitumor profile.
Chrysomycin A is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
CAS Number
82196-88-1
Molecular Formula
C28H28O9
Molecular Weight
508.5
Mechanism of Action
The mechanism of action of chrysomycins is not fully understood; however, recent research suggests chrysomycins may act as photoactivated cross-linkers of DNA to histones.
Storage Conditions
-20°C