Form

Powder

Appearance

Whiteoralmostwhitepowder

Source

Semi-synthetic

ImpurityProfile

ImpurityA|Decarbamoylcefoxitin;(6R,7S)-3-(hydroxymethyl)-7-methoxy-8-oxo-7-[[(thiophen-2-yl)acetyl]amino]-5-thia-1-azABIcyclo[4.2.0]oct-2-ene-2-carboxylicacid|54333-94-7|C₁₅H₁₆N₂O₆S₂|384.43|ImpurityB|delta-3-cefoxitin;(2RS,6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[[(thiophen-2-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylicacid||C₁₆H₁₇N₃O₇S₂|427.454|ImpurityC|cefalotinlactone;(5aR,6R)-6-[[(thiophen-2-yl)acetyl]amino]-5a,6-dihydro-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione||C₁₃H₁₂N₂O₄S₂|324.38|ImpurityD|cefoxitinlactone;(5aR,6S)-6-methoxy-6-[[(thiophen-2-yl)acetyl]amino]-5a,6-dihydro-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione||C₁₄H₁₄N₂O₄S₂|338.4|ImpurityE|(6R,7S)-3-[(carbamoyloxy)methyl]-7-(methyloxy)-7-[[(2R)-2-(methyloxy)-2-(2-thienyl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid((R)-methoxycefoxitin)||C₁₇H₁₉N₃O₈S₂|425.42|ImpurityF|(6R,7S)-3-[(carbamoyloxy)methyl]-7-(methyloxy)-7-[[(2S)-2-(methyloxy)-2-(2-thienyl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid((S)-methoxycefoxitin)||C₁₇H₁₉N₃O₈S₂|425.42|ImpurityG|(6R,7S)-3-[[[[[(6R,7S)-2-carboxy-7-(methyloxy)-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]oxy]carbamoyloxy]methyl]-7-(methyloxy)-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid(cefoxitindimer)|

WaterContent(KarlFisher)

≤5.0%

pH

2.5-3.5

OpticalRotation

+195°to+208°

Assay

≥98.0%(ondriedbasis)

Impurities

RelatedSubstances:
SingleImpurity:≤0.4%
TotalImpurities:≤1.0%