Cefsulodin sodium is a third generation cephalosporin antibiotic.

Recently, TOKU-E has found that the main cause of cefsulodin instability stems from one key impurity in 7-ACA (7-aminocephalosporanic acid- a raw material used in the synthesis of cefsulodin). In order to produce high-purity, high-stability cefsulodin, TOKU-E uses industrial HPLC to remove significant quantities of this impurity in 7-ACA and thus produce ultra-pure, ultra-stable, and ultra-potent cefsulodin.

Tian et al. used cefsulodin sodium from TOKU-E to study the mechanisms of resistance in cefsulodin-resistant Pseudomonas aeruginosa. Read more here: "CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa."

CAS Number

52152-93-9

Molecular Formula

C₂₂H₁₉N₄NaO₈S₂ · xH₂O

Molecular Weight

554.53 (Anhydrous basis)

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

Storage Conditions

-20°C

Tariff Code

2941.90.3000

Spectrum

Cefsulodin sodium has a very limited spectrum specifically targeting Pseudomonas aeruginosa. Other members of the gram positive and gram negative species show little susceptibility.

Specifications: