TAN1364BisthemostabundantanalogueofatetronicacidcomplexisolatedfromStreptomycesspecies,firstpatentedbyTakedain1993andmoreformallyidentifiedbyCibaGeigyasthesodiumsaltof3-hexadecanoyl-5-hydroxymethyltetronicacid.In1995researchersatRIKENreportedtheisolationof3-hexadecanoyl-5-hydroxymethyltetronicacid,namedasRK-682.Subsequentsynthesisin2001showedthattheRIKENRK-682wasinfactthecalciumcomplexofTAN1364Bformedasanartefactduringsilicachromatography.Asthecomplex,saltorfreeacid,TAN1364Binhibitsproteintyrosinephosphatases,phospoholipaseA2,heparinaseandHIV-1protease.However,itisunclearwhether
BIOLOGicalactivityisduetothemonomer(TAN1364B)ordimericcomplex(RK-682)
TAN1364Bissolublein ethanol,methanol,DMFandDMSO.
CASNumber
154639-24-4
MolecularFormula
C21H36O5
MolecularWeight
368.5
StorageConditions
-20°C
Specifications: