Tigecycline is a broad spectrum glycylcycline antibiotic which was developed to combat infections caused by many leading multi-drug resistant organisms. Tigecycline is structurally related to minocycline, a tetracycline antibiotic; however, it contains a large glycylamido group at the D-9 position. This substitution is thought to be the reason behind its broad spectrum activity. Tigecycline is soluble in water (0.45mg/mL) and DMSO (>3 mg/mL).

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CAS Number

220620-09-7

Molecular Formula

C₂₉H₃₉N₅O₈

Molecular Weight

585.65

Mechanism of Action

Tigecycline inhibits protein synthesis by binding to the A site of the 30S ribosomal subunit.

Storage Conditions

-20°C

Tariff Code

2941.30.0000

Spectrum

Tigecycline has broad spectrum activity against most Gram positive and Gram negative bacteria including multi-drug resistant organisms such as MRSA. Tigecycline has also been found to be effective against carbapenem resistant Enterobacteriaceae or CRE. CRE is a "superbug" which possesses NDM-1 or KPC genes which encode New Delhi Metallo-beta-lacamase or Klebsiella pneumoniae cabapenemase respectively; two enzymes which render nearly all beta-lactam antibiotics useless.

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