Cefaclor is a second generation cephalosporin antibiotic derived from the Acremonium fungus. Cefaclor is slightly soluble in aqueous solution (8.6mg/mL).

CAS Number

70356-03-5

Molecular Formula

C₁₅H₁₄ClN₃O₄S • H₂O

Molecular Weight

385.82

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

Storage Conditions

-20°C

Tariff Code

2941.90.3000

Spectrum

Cefaclor is a broad spectrum antibiotic commonly used against bacteria that cause pneumonia and meningitis such as Streptococcus pneumoniae and Haemophilus influenzae

Specifications: