Cefamandole nafate is a second generation cephalosporin antibiotic.
TOKU-E offers two forms of cefamandole: cefamandole nafate (C078), and cefamandole sodium salt (C079). In aqueous solution, cefamandole nafate is freely soluble and sparingly soluble in methanol. Cefamandole sodium is freely soluble in an aqueous solution.
CAS Number
42540-40-9
Molecular Formula
C19H17N6NaO6S2
Molecular Weight
512.49
Mechanism of Action
Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
Storage Conditions
-20°C
Tariff Code
2941.90.3000
Spectrum
Cefamandole is a broad spectrum cephalosporin targeting a wide variety of gram positive and gram negative bacteria.
Form
Powder
Appearance
White or almost white powder
Source
Semi-synthetic
Impurity Profile
|Cefamandole nafate|42540-40-9|C19H17N6NaO6S2|512.5|
|Cefamandole sodium|30034-03-8|C18H17NaO5S2|484.5|
Impurity A| formylmandeloyl-7-amino-desacetoxy-cephalosporanic acid||C16H16N2O6S|364.4|
Impurity C| O-acetylcefamandole||C18H20N6O6S2|480.5|
Impurity D| 1-methyl-1H-tetrazole-5-thiol|69713-31-1|C2H4N4S|16.145|
Impurity E| formylmandeloyl-7-ACA||C19H18N2O8S|434.4|
Water Content (Karl Fisher)
≤2.0%
pH
3.5-7.0
Assay
(On Dried Basis): 810-1000µg/mg
