Moxidectin is a semi-synthetic milbemycin derived from nemadectin by selective oxidation followed by methyloximation. Moxidectin was patented in 1991 as an anthelmintic for internal parasite control. The presence of the methyloxime affords moxidectin a greater hydrophobicity and longer biological half-life compared to nemadectin.
Moxidectin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
CAS Number
113507-06-5
Molecular Formula
C37H53NO8
Molecular Weight
639.8
Mechanism of Action
Moxidectin binds selectively to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
Storage Conditions
-20°C