MilbemycinA4oximeisasemi-syntheticmacrocycliclactonepreparedbytheoxidationandoximationofmilbemycinA4.MilbemycinA4oximeisthemajorcomponent(~70%)inthecommercialproduct,milbemycinoxime,marketedforendo-andexo-parasiteinfections.
MilbemycinA4oximeissolubleinethanol,methanol,DMForDMSO.Poorwatersolubility.
CASNumber
93074-04-5
MolecularFormula
C32H45NO7
MolecularWeight
555.7
MechanismofAction
Liketheothermilbemycin/avermectins,milbemycinA4oximeactsbyopeningglutamatesensitivechloridechannelsinneuronsofinvertebrates,leADIngtoparalysisbyhyperpolarisationofthesecellsandsignaltransferblocking.
StorageConditions
-20°C