MilbemycinA3oximeisasemi-syntheticmacrocycliclactonepreparedbytheoxidationandoximationofmilbemycinA3.MilbemycinA3oximeistheminorcomponent(~30%)inthecommercialproductmilbemycinoxime,marketedforendo-andexo-parasiteinfections.
MilbemycinA3oximeissoluble inethanol,methanol,DMForDMSO.Poorwatersolubility.
CASNumber
114177-14-9
MolecularFormula
C31H43NO7
MolecularWeight
541.7
MechanismofAction
Liketheothermilbemycin/avermectins,milbemycinA3oximeactsbyopeningglutamatesensitivechloridechannelsinneuronsofinvertebratesleADIngtoparalysisbyhyperpolarisationofthesecellsandsignaltransferblocking.
StorageConditions
-20°C