Ticarcillin disodium is an extended spectrum β-lactam in the carboxypenicillin family.

TOKU-E offers two forms of ticarcillin disodium: ticarcillin disodium (T027) and ticarcillin disodium w/clavulanate potassium (T020). Both forms are freely soluble in aqueous solution. Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Ticarcillin disodium can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.

CAS Number

4697-14-7

Molecular Formula

C₁₅H₁₄N₂Na₂O₆S₂

Molecular Weight

428.39 g/mol

Mechanism of Action

β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

Storage Conditions

2-8 °C

Tariff Code

2941.10.5000

Spectrum

Ticarcillin disodium is a broad spectrum antibiotic targeting a wide range of Gram positive and gram negative organisms.

Specifications: