Aphidicolinisatetracyclicditerpeneantibioticisolatedfromfungi,notablyCephalosporium,Nigrospora,HarziellaandPhoma.Aphidicolinhasantibiotic,antiviralandantimitoticproperties,blockingthecellcycleatearlyS-phase.Thispropertyhasbeenusedtosynchronisecelldivisionandisusefulasatoolincelldifferentiationresearch.Aphidicolininducesapoptosis,prolongsthehalf-lifeofDNAmethyltransferase,isactiveagainstLeishmaniaparasitesandactssynergisticallywiththeantitumoragents,vincristineanddoxorubicin.
Aphidicolinissolublein ethanol,methanol,DMFandDMSOandhaslimitedwatersolubility.
CASNumber
38966-21-1
MolecularFormula
C20H34O4
MolecularWeight
338.5
MechanismofAction
AphidicolinisareversIBLeinhibitorofDNAreplicationbyinhibitingselectedDNApolymerases.
StorageConditions
-20°C