Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A.
Concanamycin B is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
81552-33-2
Molecular Formula
C45H73NO14
Molecular Weight
851.5
Mechanism of Action
Concanamycin B inhibits vacuolar H(+)-ATPase and the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.
Storage Conditions
-20°C