ConcanamycinBisamacrocycliclactoneoriginallyisolatedfromStreptomycesdiastatochromogenesin1982asapotentinhibitoroftheproliferationofmousespleniclymphocytesstimulatedbyconcanavalinA.
ConcanamycinBissolublein ethanol,methanol,DMFandDMSO.
CASNumber
81552-33-2
MolecularFormula
C45H73NO14
MolecularWeight
851.5
MechanismofAction
ConcanamycinBinhibitsvacuolarH(+)-ATPaseandtheexpressionofnewly-synthesizedMHCclassIImoleculesandsuppressesboneresorptioninvitro.
StorageConditions
-20°C