Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.
Borrelidin is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
7184-60-3
Molecular Formula
C28H43NO6
Molecular Weight
489.6
Mechanism of Action
Borrelidin is a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase and is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells.
Storage Conditions
-20°C