LeptomycinBisthedominantandmoststudiedmemberoftheleptomycinclass,isolatedfromselectedStreptomycesstrains.LeptomycinBisananomolaractiveandspecificnuclearexportinhibitor.ItstargetisCRM1/exportin1,aproteininthenuclearexportsequence(NES).Proteinsaffectedincludec-Abl,cyclinB1,HIV-1Rev,IκB,MPF,MAP/ERK,MDM2/p53,NF-κB/IκB7andPKA.LeptomycinBinhibitsexportofmanyRNAs,e.g.COX-2andc-FOSmRNA.LeptomycinBalsoshowsantifungal,antibacterialandpotentantitumoractivities.
LeptomycinBissolubleinethanolormethanol.Poorwatersolubility.Ethanolrecommended.UnstableinDMSO.
CASNumber
87081-35-4
MolecularFormula
C33H48O6
MolecularWeight
540.7
StorageConditions
-20°C
Specifications: