Kazusamycin A is a minor member of the leptomycin complex isolated from some Streptomyces species. It is an hydroxylated analogue of leptomycin B, a nuclear export inhibitor. Kazusamycin A exhibits potent antitumor activity both in vitro and in vivo against P388 and L1210 cell lines, and also shows strong antibacterial and antifungal activity.
Kazusamycin A is soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
CAS Number
92090-94-3
Molecular Formula
C33H48O7
Molecular Weight
556.7
Storage Conditions
-20°C
Specifications:
Appearance
Colourless Film