Hygrolidinisa16-memberedmacrocycliclactonecloselyrelatedtothebafilomycins,activeagainstValsaceratosperma,thepathogenofapplecankerdisease.HygrolidinisactiveagainstSV40tumorcells,andinhibitsthegrowthofsolidtumor-derivedcelllinessuchasDLD-1humancoloncancercellswithincreasedcellsinG1andSphases.Hygrolidindecreasescyclin-dependentkinase(cdk)4,cyclinDandcyclinB,andincreasescyclinEandp21levels.Hygrolidin-inducedp21inhibitscyclinA-cdk2complexmorestronglythancyclinE-cdk2complex.Italsoincreasesp21mRNAinDLD-1cells,butnotinnormalfibroblasts.
Hygrolidinissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
83329-73-1
MolecularFormula
C38H58O11
MolecularWeight
690.9
StorageConditions
-20°C
Specifications: