KigamicinCwasdiscoveredbyananti-austeritystrategy,targetingcancercells"tolerancetostarvation.ItselectivelykillsPANC-1cells(apancreaticcellline)atconcentrations100timeslowerundernutrientstarvedconditionsthaninnormalconditions.Itisactiveinvivoagainstahumanpancreaticcancerxenograftmodel.KigamicinCalsoinhibitsthegrowthofGrampositivebacteriaincludingMRSA,butisnotactiveagainstGramnegativebacteria.
KigamicinCissolubleinethanol,methanol,DMForDMSO.Poorwatersolubility.
CASNumber
680571-51-1
MolecularFormula
C41H47NO16
MolecularWeight
809.8
MechanismofAction
ThemechanismofactionisproposedtobeviablockadeofaPKB/Aktactivation,causedbythewithdrawalofnutrients.
StorageConditions
-20°C