AureothricinisanantibioticfirstdescribedbyUmezawaandco-workersinJapanin1949.Resurgentinterestinthisclassofmicrobialmetaboliteswasstimulatedbythediscoveryoftheirselectiveantitumoractivity.Aureothricinisamorehydrophobicanalogueofthiolutin,buthasreceivedonlylimitedattention.Membersofthisclass,notablythiolutin,arepotentinhibitorsofbacterialandyeastRNApolymerases,inhibitorsofmannanandglucanformationinfungi,andinhibitorsoftumor-cellinducedangiogenesisinvivo.
Aureothricinissolublein DMFandDMSOandismoderatelysolubleinmethanolandethanol.
CASNumber
574-95-8
MolecularFormula
C9H10N2O2S2
MolecularWeight
242.3
StorageConditions
-20°C
Specifications:
Appearance
Yelloworangesolid