Colistin is a unique sparingly soluble cyclic polypeptide antibiotic known as a polymyxin. Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability. New Delhi metallo-β-lactamase multidrug-resistant Enterobacteriaceae have also shown susceptibility to Colistin.

TOKU-E offers two forms of colistin: colistin sulfate (C083) and colistin sodium methanesulfonate (C073) (also known as colistimethate sodium). Both forms of colistin are freely soluble in aqueous solution.  Colistin sodium methanesulfonate (CMS) is considered an inactive prodrug which means it is inactive until converted into colistin by cellular enzymes.  Colistin sulfate (colistin) however, is the end product of CMS and does not require molecular conversion for antimicrobial properties. To see all available colistin products, click here.

CAS Number

8068-28-8

Molecular Formula

C₅₈H₁₁₅N₁₆Na₅O₂₈S₅

Molecular Weight

1759.90

Mechanism of Action

Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability.

Storage Conditions

2-8 °C

Tariff Code

2941.90.1050

Spectrum

Colistin primarily targets and disrupts the cell wall of gram negative bacteria.

Specifications: