Daptomycin is a unique lipopeptide antibiotic frequently used to treat Gram-positive bacterial infections including those caused by a few drug resistant organisms. Daptomycin is soluble in water (100 mg/mL), DMSO (100 mM), methanol (mg/mL), and ethanol (50 mM).

CAS Number

103060-53-3

Molecular Formula

C₇₂H₁₀₁N₁₇O₂₆

Molecular Weight

1620.67

Mechanism of Action

Daptomycin peptides initially interact with anionic phospholipids in the membrane of Gram-positive bacteria. The peptides then integrate in the membrane by a calcium-mediated process and interact with membrane phospholipid head groups and acyl chains. Finally, a pore or channel is formed which can kill the cell by membrane disruption/depolarization or cellular uptake of daptomycin leading to disruption of intracellular processes.

Storage Conditions

-20°C

Tariff Code

2941.90.3000

Spectrum

Daptomycin targets only Gram-positive organisms including GRE (glycopeptide-resistant Enterococci) and MRSA (Methicillin Resistant Staphylococcus aureus)

• Vancomycin resistant Enterococcus faecalis - ≤0.015 μg/mL － 4 μg/mL
• Methicillin resistant Staphylcoccus aureus - 0.25 μg/mL - 2 μg/mL

For a complete list of daptomycin MIC values, click here.

Specifications: