Form

Powder

Appearance

Whiteoralmostwhitepowder

Source

Semi-synthetic

ImpurityProfile

ImpurityA|(6R,7R)-7-amino-3-[[(5-methyl-1,3,4-thiADIazol-2-yl)sulphanyl]methyl]-8-oxo-5-thia-1-azABIcyclo[4.2.0]oct-2-ene-2-carboxylicacid|30246-33-4|C₁₁H₁₂N₄O₃S₃|344.44|ImpurityB|(6R,7R)-7-[(2,2-dimethylpropanoyl)amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulphanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid||C₁₆H₂₀N₄O₄S₃|428.55|ImpurityC|(6R,7R)-3-methyl-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid|56842-77-4|C₁₁H₁₂N₆O₄S_{|324.32|ImpurityD|(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid|32510-61-5|C13H14N6O6S|382.36|ImpurityE|MMTD|29490-19-5|C3H4N2S2|132.2|ImpurityG|(5aR,6R)-6-[(1H-tetazol-1-ylacetyl)amino-5a,6-dihydro3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione||C11H10N6O4S|322.30|ImpurityH|7-ACA|957-68-6|C10H12N2O5S|272.28|ImpurityI|cefazoloicacid;2-[carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylicacid||C14H16N8O5S3|472.53|ImpurityJ|hydrolysedcefazoloicacid;2-[carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-(hydroxymethyl)-5,6-dihydro-2H-1,3-thiazine-4-carboxylicacid||C11H14N6O6S|358.33|ImpurityK|Cefazolinamide;(6R,7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxamide||C14H15N9O3S3|453.53|ImpurityL|(6R,7S)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulphanyl]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid1H-Tetrazole-1-aceticacid|21732-17-2|C3H4N4O2|128.09|}

WaterContent(KarlFisher)

≤6.0%

pH

4.0-6.0

OpticalRotation

-10°to-24°

Assay

(OnDriedBasis):89.1-110.1%