Cefdinir is a broad spectrum third generation cephalosporin antibiotic resistant to many β-lactamase enzymes.  Cefdinir is highly soluble in aqueous solution (87.2 mg/mL).

Kaul et al. used cefdinir from TOKU-E to study synergistic effects of cefdinir and the prodrug, TXA709 against Methicillin-Resistant Staphylococcus aureus (MRSA)."Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin cefdinir confers synergy and reduces the frequency of resistance in Methicillin-resistant Staphylococcus aureus." 

CAS Number

91832-40-5

Molecular Formula

C₁₄H₁₃N₅O₅S₂

Molecular Weight

395.42

Mechanism of Action

Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases, however, cefdinir is not typically inactivated by this mechanism.

Storage Conditions

-20°C

Tariff Code

2941.90.5000

Spectrum

Cefdinir is a broad spectrum antibiotic targeting both gram positive and gram negative pathogens responsible for ear, sinus and skin infections.

Specifications: