Cefdinirisabroadspectrumthirdgenerationcephalosporinantibioticresistanttomanyβ-lactamaseenzymes. Cefdinirishighlysolubleinaqueoussolution(87.2mg/mL).
Kauletal. used cefdinir fromTOKU-Etostudysynergisticeffectsofcefdinirandtheprodrug,TXA709againstMethicillin-ResistantStaphylococcusaureus(MRSA)."CombiningtheFtsZ-TargetingProdrugTXA709andtheCephalosporincefdinirconferssynergyandreducesthefrequencyofresistanceinMethicillin-resistantStaphylococcusaureus."
91832-40-5
C14H13N5O5S2
395.42
CephalosporinsinterferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetocephalosporinsiscommonlyduetocellscontainingplasmidencodedβ-lactamases,however,cefdinirisnottypicallyinactivatedbythismechanism.
-20°C
2941.90.5000
CefdinirisabroadspectrumantibiotictargetingbothgrampositiveandgramnegativepathogensresponsIBLeforear,sinusandskininfections.
Powder
Whiteorlightyellowpowder
Synthetic
≤3.0%
-67°to-61°
(OnDriedBasis):960-1020µg/mg
≤0.2%
ImpurityG:≤0.7%
SingleImpurity:≤0.2%
TotalImpurities:≤3.0%
