Nystatin is polyene antifungal containing a conjugated tetraene and a diene, isolated as a complex of three components A1, A2 and A3 from Streptomyces noursei and first reported in 1950. Nystatin is an established bioprobe and widely-used antifungal reagent with over 4,000 literature citations.
Nystatin A1 is soluble in DMF or DMSO, and moderately soluble in methanol or ethanol. Poor water solubility.
CAS Number
1400-61-9
Molecular Formula
C47H75NO17
Molecular Weight
926.1
Mechanism of Action
Nystatin, like most polyene antifungals, binds to sterols in the fungal cell membrane leading to formation of ion channels in the wall, ion imbalance and cell death.
Storage Conditions
-20°C