Cefepime is a fourth generation cephalosporin antibiotic.

TOKU-E offers two forms of cefepime: cefepime (C008), and cefepime HCl (C009). In aqueous solution, cefepime is slightly soluble (17.3 mg/mL) compared to the more soluble cefepime HCL (40 mg/mL). Both forms have similar potencies and are suitable for microbiology use; however, cefepime HCl is easier to work with in aqueous solution because of its higher solubility.

CAS Number

88040-23-7

Molecular Formula

C₁₉H₂₄N₆O₅S₂

Molecular Weight

480.56

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Interestingly, cefepime is resistant to various β-lactamases encoded by otherwise resistant β-lactam bacteria strains.

Storage Conditions

-20°C

Tariff Code

2941.90.5000

Spectrum

Cefepime is a broad spectrum antibiotic targeting a wide variety of naturally antibiotic resistant gram positive and gram negative bacteria. Some of these naturally resistant bacteria include Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.

Specifications: