Form
Powder
Appearance
White or almost white crystalline powder
Source
Semi-synthetic
Water Content (Karl Fisher)
3.0-6.0%
Absorbance
A400≤0.2
Assay
(On Dried Basis): 825 – 911 μg/mg
Cefepime HCl is a fourth generation cephalosporin antibiotic.
TOKU-E offers two forms of cefepime: cefepime (C008), and cefepime HCl (C009). In aqueous solution, cefepime is slightly soluble (17.3 mg/mL) compared to the more soluble cefepime HCL (40 mg/mL). Both forms have similar potencies and are suitable for microbiology use; however, cefepime HCl is easier to work with in aqueous solution because of its higher solubility.
123171-59-5
C19H25ClN6O5S2 · HCl · H2O
571.50
Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Interestingly, cefepime is resistant to various β-lactamases encoded by otherwise resistant β-lactam bacteria strains.
-20°C. Protect from light.
2941.90.5000
Cefepime is a broad spectrum antibiotic targeting a wide variety of naturally antibiotic resistant gram positive and gram negative bacteria. Some of these naturally resistant bacteria include Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.
Powder
White or almost white crystalline powder
Semi-synthetic
3.0-6.0%
A400≤0.2
(On Dried Basis): 825 – 911 μg/mg