MonensinAisapolyetherantibioticfirstisolatedfromStreptomycescinnamonensisin1967.MonensinAisabroad-spectrumanticoccicidalantibiotic,alsoexhibitingantifungalandantiviralactivity.MonensinAblocksintracellularproteintransportandisusedinanimalstopreventcoccidiosis,promotegrowthandpreventbloat.Derivativesofmonensin,monensinmethylesterandparticularlymonensindecylester,areusedinionselectiveelectrodes.
MonensinAissolubleinethanol,methanol,DMForDMSO.Poorwatersolubility.
CASNumber
17090-79-8
MolecularFormula
C36H62O11
MolecularWeight
670.8
MechanismofAction
MonensinAformscomplexeswithmonovalentcationssuchasLi+,Na+,K+,Rb+,Ag+andTl+andisthusabletotransportthesecationsacrosslipidmembranesofcells,playinganimportantroleasanNa+/H+antiporter.
StorageConditions
-20°C