Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp.. It is an hydroxylated analogue of leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumor activity against L1210 and human colon adenocarcinoma, and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity.
Kazusamycin B is soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
CAS Number
107140-30-7
Molecular Formula
C32H46O7
Molecular Weight
542.7
Storage Conditions
-20°C
Specifications:
Appearance
Colourless Film